Fighting health risks induced by premature birth in adults
The miniNO project is a European funded research initiative investigating why babies born prematurely will experience more health issues later in life, called comorbidities. Prematurity can indeed trigger an altered maturation of the brain in infants, leading to a condition called minipuberty. The miniNO project will research how minipuberty, nitric oxide signalling in the brain and comorbidities appearing later in life are linked. Researchers hope to improve the quality of life of millions of prematurely born individuals in the world. This project gathers 10 teams of researchers, clinicians and companies working all around Europe together from 2020 to 2026.
Understand the basic biological mechanisms of neuroendocrine development occurring during early postnatal life
Investigate the association between premature birth and its comorbidities with the maturation of the HPG axis during minipuberty
Investigate the effect of NO during minipuberty in preterm and full-term infants
Perform a prospective study using two pre-existing European cohorts of patients born prematurely
Exploit data to establish a potential link between altered minipuberty and sex, environmental, lifestyle and socio-economic factors