Years duration
2020-2026
International
partners
Countries
European
funding (M€)
Fighting health risks induced by premature birth in adults
The miniNO project focuses on the critical first 1000 days of human life, crucial for brain and overall development. Prematurity disrupts this process, altering brain maturation and minipuberty – a key phase regulating vital functions. By investigating the relationship between minipuberty, brain nitric oxide signaling, and later-life health issues, the project aims to improve outcomes for millions of prematurely born individuals. With 10 teams across Europe collaborating from 2020 to 2026, it promises impactful advancements in premature birth research.
OBJECTIVES
GOAL 1
Understand the basic biological mechanisms of neuroendocrine development occurring during early postnatal life
GOAL 2
Investigate the association between premature birth and its comorbidities with the maturation of the HPG axis during minipuberty
GOAL 3
Investigate the effect of NO during minipuberty in preterm and full-term infants
GOAL 4
Perform a prospective study using two pre-existing European cohorts of patients born prematurely
GOAL 5
Exploit data to establish a potential link between altered minipuberty and sex, environmental, lifestyle and socio-economic factors
